Web1 aug. 2024 · Some lysosomotropic compounds used in experimental work on endolysosomal trafficking and function include the tricyclic antidepressants, imipramine and amitriptyline; the antipsychotic, chlorpromazine; and the selective serotonin re-uptake inhibitor, fluoxetine [50]. Web24 mrt. 2024 · agents with lysosomotropic properties might also demonstrate clinical effectiveness in the treatment of COVID-19. In this review, we discuss commonly used …
Widely available lysosome targeting agents should be ... - Preprints
Web25 aug. 2024 · lysosomotropic drugs. These agents commonly the formation of LRRK2promoted - coated enlarged lysosomes and extracellular release of lysosomal enzyme cathepsin B, the latter being dependent on LRRK2 kinase activity. In contrast to the increase in Rab10 phosphorylation, treatment with ysosomotropic drugs dl not increase … WebWith the aim to identify other lysosomotropic drugs with possible inherent antiviral activity, we have applied a set of clear physicochemical, pharmacokinetic and molecular criteria … dance to the rhythm of the night
Lysosomotropic agents as HCV entry inhibitors - Virology Journal
Web19 okt. 2024 · Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological studies reporting lower cancer incidence in individuals receiving long term drug treatment.Experimental … Web9 feb. 2024 · Resistance to the anti-cancer effects of chemotherapeutic agents (chemoresistance) is a major issue for people living with cancer and their providers. A diverse set of cellular and inter-organellar signaling changes have been implicated in chemoresistance, but it is still unclear what processes lead to chemoresistance and … WebThe use of lysosomotropic agents offers a new treatment possibility since they disrupt lysosomal membranes and can trigger a series of events leading to cell death. In addition, combining lysosome disrupting agents with targeted inhibitors can … bird with white stripe on wings