Chromopyrrolic
WebJun 12, 2014 · With this methodology, several key intermediates of natural products have been effectively prepared, and the total syntheses of lycogarubin C and chromopyrrolic acid have been completed in high efficiency. Supporting Information Spectral data ( 1 H and 13 C) and data for the X-ray analysis. WebDichlorochromopyrrolate synthase ( EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3- (7-chloroindol-3-yl)propanoate …
Chromopyrrolic
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WebChromopyrrolic Acid. Chromopyrrolic acid (55) formation is catalyzed by the chromopyrrolic acid synthase ClaD. From: The Alkaloids: Chemistry and Biology, … WebMay 20, 2024 · 除以上概述的结构类型外，在深海链霉菌生物碱类化合物的生物合成基因簇中也发现了P450酶基因的踪迹.Ma等[78]在研究一株来自深海的链霉菌Streptomycessp.SCSIO 03032中产生的具有抗菌、抗肿瘤活性的吲哚咔唑类生物碱spiroindimicins的生物合成机制时发现，P450酶编码 ...
WebHoward-Jones, Annaleise R., Walsh, Christopher T. (2006) Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and … WebSep 1, 2006 · StaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant product, while the presence of RebC directs formation of arcyriaflavin A. (18)O-Labeling studies indicate that the oxygen(s) of the pyrrolinone and maleimide …
WebOverall formation of aglycones K252c and arcyriaflavin A from their biosynthetic precursor chromopyrrolic acid involves four- and eight-electron oxidations, respectively. This … WebDec 29, 2004 · In agreement with this hypothesis, no chlorination of chromopyrrolic acid or arcyriaflavin was detected when we fed either of these compounds to a S. albus strain expressing rebH. In contrast, coexpression of rebODH or rebOD-CPH yielded chloro and dichloro versions of chromopyrrolic acid (compounds 7 and 8 ) and arcyriaflavin …
Chromopyrrolic acid is a pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups. It has a role as a bacterial metabolite. It is a member of indoles and a pyrroledicarboxylic acid.
WebJul 3, 2014 · An effective and concise approach to synthesis of tetrasubstituted pyrroles from readily available amino acid esters by the promotion of Cu (OAc)2 in conjunction with Mn (OAc)3 has been developed. This reaction proceeds through multiple dehydrogenations, deamination, and oxidative cyclization. list of phone scam numbersWebMar 15, 2009 · The resultant strain yielded chromopyrrolic acid that was purified and identified by LC-ESI MA and NMR. The work described in this study may serve as a … img css alignWebA pair of genes (vioAB), responsible for the earliest steps in violacein biosynthesis, was functionally equivalent to the homologous pair in the indolocarbazole … img crownWebMay 1, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; … list of phonetic sounds in englishWebMay 20, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; … img crown energy servicesWebMolecules 2024, 25, 256 8 of 16 Gene expression elucidated that 3 is solely required by the tetrameric hemoprotein StaD or RebD for the production of the chromopyrrolic acid 4 in staurosporine or rebeccamycin biosynthesis [45,49], contrary to the previous reports that both 2 and 3 are the precursors for the coupling reaction to yield 4 [38,45]. img crown reclinerWeb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 list of phonic sounds