Aldh1l1-cre小鼠
http://www.labmodel.cn/mod_product-view-p_id-4107.html Web条件性敲除小鼠定义:条件性基因敲除小鼠(也叫Flox小鼠)是指在目的基因中含有成对的loxp位点的小鼠,与Cre工具小鼠交配后可在特定的组织或细胞中敲除目的基因。lCKO如何实现?重组酶系统(如:Cre-loxP)介导的位点特异性重组技术。Cre是重组酶(38kDa),可识别34bp长的DNA序列loxP。
Aldh1l1-cre小鼠
Did you know?
WebAldh1l1-CreERT2小鼠. 该Cre小鼠与FloxP小鼠交配后,在Cre特异表达的组织或者器官或细胞中,两个FloxP位点间的外显子或元件将被删除,达到条件性敲除或过表达的目的。. … WebDec 2, 2024 · University of California San Diego, La Jolla, California, United States . Background: Human brain functions, including perception, attention, and other higher-order cognitive functions, are supported by neural oscillations necessary for the transmission of information across neural networks. Previous studies have demonstrated that the …
Web023748 B6;FVB-Tg(Aldh1l1-cre)JD1884Htz/J This transgenic strain expresses cre recombinase from the mouse Aldh1l1 (aldehyde dehydrogenase 1 family, member L1) … WebRRID:IMSR_JAX:007908. Common Name: Ai14 , Ai14D or Ai14 (RCL-tdT)-D. A C57BL/6J-congenic version of this strain is available as Stock No. 007914. Ai14 is a Cre reporter allele designed to have a loxP -flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt ...
Web将Cre定点敲入大鼠内源ALDH1L1基因位置,建立ALDH1L1-Cre工具鼠,用来与flox大鼠杂交实现组织特异性敲除大鼠。基因敲入,胚胎冷冻. 模型表型数据: 乙醛脱氢酶1L1 (Aldehyde dehydrogenase 1L1, ALDH1L1)作为乙醛脱氢酶超家族成员中重要的一员,在体内叶酸代谢过程中发挥重要 ... WebAi14小鼠在Cre介导的重组后表达稳定的tdTomato红色荧光。Ai14可能在暴露于Cre重组酶之前表现出低水平的tdTomato表达,但Cre重组后的tdTomato表达水平明显大于这些基线 …
WebMay 13, 2024 · 为了高特异性和高时间分辨率检测睡眠觉醒周期中BF胞外腺苷浓度的动态变化,李毓龙教授组开发了腺苷探针(GRABAdo),该探针的检测原理是基于腺苷G蛋白偶联受体的激活,使胞外腺苷的浓度通过绿色荧光蛋白的荧光强度来测量。. 作者从灵敏性、特异 …
Web023748 B6;FVB-Tg(Aldh1l1-cre)JD1884Htz/J This transgenic strain expresses cre recombinase from the mouse Aldh1l1 (aldehyde dehydrogenase 1 family, member L1) promoter. This strain enables tissue-specific excision of floxed genomic segments in astrocytes as well as some oligodendrocytes and neurons. josh turner grand ole opry 2021WebSep 7, 2024 · Recently, Aldh1L1 has been shown to be a pan-astrocyte marker and that its promoter can be used to specifically target astrocytes using the Cre-loxP system. In this study we explored whether the recently described Aldh1L1-CreER T2 mouse line (Winchenbach et al., 2016) can serve to specifically target niche astrocytes without … josh turner go tell it on the mountainhttp://www.bioon.com.cn/news/showarticle.asp?newsid=82362 how to link pc to onedriveWebALDH1L1. 10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene. [5] The protein encoded by this gene catalyzes the … josh turner haywire deluxe editionWeb醛脱氢酶 1 家族成员 l1 (aldh1l1) 是叶酸代谢中的一种关键酶,因此在细胞代谢和增殖的调节方面起着重要作用。已在肿瘤中发现 aldh1l1 下调,导致对癌细胞增殖的抑制减弱。靶 … how to link pc maple to maplestory mWeb资源中文名称. ALDH1L1 基因敲除大鼠. 资源英文名称. SD. ALDH1L1 (TM )-GC/ILAS. 疾病概述. 神经疾病相关. 实验动物背景信息. 背景品系为SD (Sprague Dawley, SD)大鼠 ,为大鼠(rat;rattus norregicus)的一个品系,属于动物界、脊索动物门、脊椎动物亚门、哺乳纲、啮齿目、鼠科 ... josh turner good ol boysWebHere we developed and characterized an AAV vector expressing Cre recombinase under the human ALDH1L1 promoter, AAV-hALDH1L1-Cre. To test the cell-type specific expression of AAV-hALDH1L1-Cre, AAV virus was injected into several brain regions of Ai14 (RCL-tdTomato) mouse, which reports Cre activity by tdTomato expression. In thalamus, … josh turner h5 zoom interface